Discontinuation of acid blockers: What’s behind the Rebound phenomenon?

Pantoprazole or omeprazole are drugs that cause the stomach makes less acid. So you can inflammation to relieve discomfort triggered by acid in the stomach, for example heartburn or esophagus in the gastroesophageal reflux disease.

Reflux patients have acid-blocker is usually permanently prescribed. Since the long-term therapy, however, involves certain risks, it may be useful, these – in consultation with the doctor to cancel. The Problem is that Some patients suffer after the Discontinuation of medicines under increased Reflux complaints.

Sometimes they interpret this as a sign that has exacerbated the illness, and you have to take the drugs Willy-nilly but. But this is a mistake. The reason for the increased Reflux complaints is the so-called acid-Rebound: The body responds to the decreased amount of stomach acid by the neurotransmitter Gastrin forms, of the acid production in the stomach stimulates. As soon as the effect of the Antacids wears off, it results in an Excess of stomach acid – but luckily only in the short term:

The Rebound caused complaints

  • usually start a few days to four weeks after taking the last tablet and
  • as a rule, at the latest after four weeks.

What helps?

Completely prevent the acid Rebound can. However, there are two ways to mitigate it:

You can’t put the taking it easy?

The safety of acid-blockers is medical controversial, because the study location is not unique. Well it is proven that the proton pump inhibitor over a longer period of time taken

  • the risk for bacterial respiratory and gastrointestinal infections, as well as for bone fractures increase and
  • cause the body absorbs too little of certain nutrients (e.g., Vitamin B12), which can lead to a deficiency.

Therefore, it is for Reflux-patients are recommended to try their complaints differently in the handle to get. Sometimes simple measures help. For instance, it helps many sufferers to sleep with elevated upper body and to avoid certain foods and drinks. Often, for example, coffee, alcohol, oily food and citrus fruits are problematic. In obese patients, the symptoms can be improved often, if you remove it.


Reflux disease: PPI is not always the first choice. Online information of the Pharmaceutical newspaper: www.pharmazeutische-zeitung.de (version: 2.5.2019)

Proton-Pump Inhibitors. Online information of the Pschyrembel: www.pschyrembel.de (June 2018)

Kim, J., et al.: Strategies for Effective Discontinuation of Proton Pump Inhibitor. Current Gastroenterology Reports, Vol. 20, Iss. 6 (may 2018)

Steel, V.: Bye-bye, PPI. DAZ, no. 34, p. 36 (August 2017)

Graefe, K. H., et al.: Dual series of pharmacology and toxicology. Thieme, Stuttgart, 2016

For More Information

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  • Reflux disease: causes & Treatment
  • So proton pump inhibitors may not work

*The contribution of “Discontinuation of acid blockers: What is behind the “Rebound phenomenon”?” is published by Onmeda. Contact with the executives here.